Abstract: Two-mass model (SH model) ignores the influence of elastic force on vocalization system and the role of viscous airflow in glottis closure in pathological voice simulation.In this paper,an asymmetric viscous aerodynamic acoustic model (ISAC model) is proposed.The impact force on the mass block is corrected by analyzing the additional elastic coefficient and elastic deformation of asymmetric vibration.The stiffness coefficient in the original model is adjusted with the change of displacement and the tension effect of cricothyroid muscles and arytenoid muscles was simulated.The continuous distribution of asymmetric viscous airflow pressure on the vocal cord wall is obtained by changing glottis inclination angle.When the model is applied to the diagnosis of vocal pathology,the results of model simulation and pathological classification show that the relative error of feature parameters of glottis is no more than 1.5%,the weighted mean error of ISAC model is lower than SH model,and the binary recognition rate and subdivision accuracy rate are higher than SH model.