Abstract: In medical ultrasound imaging field,in order to obtain high resolution and correct the phase errors induced by the velocity inhomogeneity of the tissue,a high-resolution medical ultrasound imaging method combining minimum variance beamforming and general coherence factor is presented.Firstly,the data from the elements is delayed for focusing; then the multi-channel data is used for minimum variance beamforming;at the same time,the data is transformed from array space to beam space to calculate the general coherence factor;in the end,the general coherence factor is used to weight the results of minimum variance beamforming.The medical images are gotten by the imaging system.The experiments based on point pattern and speckle pattern are used to verify the proposed method.The results show the proposed method in the aspects of resolution,contrast and robustness is better than the minimum variance beamforming and conventional beamforming.