Abstract: To detect the echo irradiated by microbubble out from the signal reflected by surrounding tissues, a mother wavelet named bubble wavelet according to the modified Herring oscillation equation was constructed and then applied to the original ultrasound radio frequency signal to perform the wavelet transformation.The transformed wavelet coefficients were extracted by selected threshold values to differentiate the echo of microbubble from signal of surround tissues. The effect of bubble wavelet was compared with other three commonly used mother wavelets by computer simulation and phantom experiment. The results demonstrated that there existed a highly correlation between the bubble wavelet and the experimental echo irradiated by microbubble because bubble wavelet had represented the dynamics of microbubble in advance. Furthermore, the wavelet transform results showed a better signal-noise-ratio and a sharper contrast between the echo of microbubble and the signal of sourrounding tissues. Finally, constructing an overall mother wavelet library can improve the applicability and robustness of this detection method.