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强噪声暴露后豚鼠听皮层调频诱发反应的变化

CHANGES OF CORTICAL FM-EVOKED RESPONSES IN GUINEA PIGS AFTER EXPOSURE TO INTENSIVE NOISE

  • 摘要: 在强噪声暴露后豚鼠听皮层对纯音调频的诱发电位振幅增大,对多数载波频率及在多数情况下调频诱发反应阈(△Fm)则明显地降低。以反应阈降低的全部数据计算,暴露后△Fm平均约降至暴露前的一半,在少数例子中降至暴露前的1/5,甚至更低。噪声暴露后诱发电位振幅的增大可以认为是由噪声引起的皮层活动某种易化的表现。△Fm的降低则倾向于提示,此种皮层易化反映暂时的功能变化,它使听觉分辨暂时得到改善。

     

    Abstract: After exposure either to a steady intensive noise (white noise, repetitive clicks, or narrow band noise, all of 110 dB SPL and 15 minute duration) or to impulse noise (300 impulses of 150 dB peak SPL and 50 ms impulse duretion) amplitudes of the evoked potentials recorded from the primary auditory cortex of guinea pigs in response to frequency modulation of pure tones were found to be systematically augmented while the response thresholds (△Fm) markedly lowered for most carrier frequencies and in most conditions. For all threshold lowering cases, the averaged △Fm shift was about 1/2 of their pre-exposure values, with some extreme examples where post-exposure △Fm could be as small as only 1/5 of the pre-exposure ones or even lower. Post-exposure amplitude augmentation of evoked responses can be considered as a sign of certain cortical facilitation induced by noise. Lowering of △Fm tends to suggest that such cortical facilitation implies some temporary functional change in the sense of improving auditory discrimination.

     

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